Research Fellow in Pharmacology

This Research Fellow position focuses on the evolutionary origins and diversification of sensory receptor and ion channel systems, specifically TRP channels. The role involves molecular and functional characterization of candidate receptors using molecular cloning, heterologous expression in mammalian cells, and pharmacological assays. A PhD in a relevant biological discipline and experience with molecular biology techniques are required.

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• You will have a PhD, or be close to completing one, in a relevant discipline such as pharmacology, molecular biology, neuroscience, biochemistry, physiology or evolutionary biology.
• You will have experience in molecular biology, cloning and construct preparation, and experience using heterologous expression systems. Experience with mammalian cell culture and functional receptor or ion-channel assays using fluorescence- or luminescence-based readouts would be desired.
• You should be confident analysing quantitative experimental data, including concentration–response experiments, EC50 determination and statistical analysis.
• Experience with ion channels, GPCRs or TRP channels, plate-reader-based assays, high-throughput screening, Xenopus oocyte expression or electrophysiology would be advantageous.
• Preferably using R or python.
• An interest in evolutionary biology, comparative genomics or the biology of early-diverging animals would be beneficial, although applicants primarily trained in molecular pharmacology, cell biology or related disciplines are strongly encouraged to apply.
• You will be expected to work independently while contributing to a collaborative and interdisciplinary research programme.
• Good organisation, careful experimental record keeping and a commitment to reproducible research are important.
• You should also be comfortable communicating your findings through publications, conference presentations and interactions with collaborators from different disciplines and institutions.
• The University of Southampton offers a range of benefits, including a generous holiday allowance and additional University closure days.
• We support flexible working and a healthy work–life balance, alongside access to the Universities Superannuation Scheme (USS), subsidised health and fitness facilities and a range of staff discounts.
• This post is offered on a three-year fixed-term basis.
• For additional information please contact Dr Luis Yanez-Guerra ( l.a.yanez-guerra@soton.ac.uk ), University of Southampton.