Research Fellow (Electron Microscopy) - School of Biosciences - 95800 - Grade 7

This is a fixed-term Research Fellow position in integrative structural biology, focusing on RNA metabolism and gene expression regulation using cryo-EM and NMR. The role requires proficiency in single-particle cryo-EM data acquisition and analysis, along with molecular biology and biophysical techniques. Candidates must hold a PhD in a relevant field and have experience in cryo-EM sample preparation and scientific writing.

• The responsibilities may include some but not all of the responsibilities outlined below.
• Contribute to writing bids for research funding
• Apply knowledge in a way which develops new intellectual understanding
• Disseminate research findings for publication, research seminars etc
• Contribute to developing new models, techniques and methods
• Undertake management/administration arising from research
• Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Deal with problems that may affect the achievement of research objectives and deadlines
• Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
• Promotes equality and values diversity, acting as a role model and fostering an inclusive working culture.
• this may be through a variety of research methods, such as scientific experimentation and literature reviews
• Contribute to Departmental/Institute research-related activities and research-related administration
• Develop research objectives and proposals for own or joint research, in the area of interest of the hosting laboratory (Prof T Carlomagno)
• Acquire, analyse and interpret data - structural biology, biochemical and biophysical data
• Acquire, analyse and interpret high-resolution single-particle cryo-EM data
• Operate the cryo-EM microscope
• Produce biomolecular complexes by molecular biology techniques
• Optimize sample production and purification, as well as preparation of cryo-EM grids
• Establish protocols for cryo-EM data analysis, from micrographs to structures

• High level analytical capability
• Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
• Ability to assess resource requirements and use resources effectively.
• Understanding of and ability to contribute to broader management/administration processes
• Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day-to-day activity in own area that those with protected characteristics are treated equally and fairly.
• Experience in scientific writing and publication in peer-reviewed journals
• Ability to work independently and collaborate effectively with multidisciplinary teams in an international research environment, ensuring the efficient coordination of activities and avoiding conflict or duplication of effort
• Understanding of, and ability to contribute to, the planning, organisation, management, and administration of broader research programmes, as well as specific research projects
• Willingness to work in a competitive, international environment
• Informal enquiries to Teresa Carlomagno, email: t.carlomagno@bham.ac.uk
• PhD (or near to completion) in Biophysics/ Biochemistry/ Chemical Biology/ Structural Biology or related areas or equivalent qualifications
• Proficiency in single-particle Electron Microscopy (cryo-EM), including data acquisition, image processing, three-dimensional reconstruction and structural analysis
• Practical experience in a biochemical laboratory and/or handling nucleic acids
• Proficiency in sample preparation for cryo-EM
• Ability to communicate complex information clearly through both written and oral communication