Research Fellow - Department of Cancer and Genomic Sciences - 106039 - Grade 7

This fixed-term Research Fellow position investigates PRMT5 oncogenic mechanisms in Ewing sarcoma, focusing on DNA damage response and splicing. Responsibilities include driving independent research using cell culture, biochemistry, and genomic analysis techniques. Essential qualifications include a relevant PhD, strong analytical skills, and experience with mouse models and advanced lab methods.

• The responsibilities may include some but not all of the responsibilities outlined below.
• Develop research objectives and proposals for own or joint research, with assistance of a mentor if required
• Contribute to writing bids for research funding
• Analyse and interpret data
• Apply knowledge in a way which develops new intellectual understanding
• Disseminate research findings for publication, research seminars etc
• Contribute to developing new models, techniques and methods
• Undertake management/administration arising from research
• Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader
• this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Deal with problems that may affect the achievement of research objectives and deadlines
• Fosters a fair and equitable workplace for all staff
• Identify and respond to equality and diversity issues in line with relevant university policies and procedures
• Other relevant criteria from our equality and diversity duties document.
• Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
• Contribute to Departmental/School research-related activities and research-related administration
• Provide guidance, as required, to support staff and any students who may be assisting with the research
• These indicative responsibilities may also be included in a research role at grade 6.

• A PhD relevant to the research area (or near completion), or equivalent PhD level qualifications.
• High level analytical capability
• Ability to communicate complex information clearly
• Ability to assess resource requirements and use resources effectively.
• Understanding of and ability to contribute to broader management/administration processes
• Contribute to the planning and organising of the research programme and/or specific research project
• Co-ordinate own work with others to avoid conflict or duplication of effort
• Knowledge of the protected characteristics and duties under the Equality Act 2010. Including fostering good relations and advancing the universities Public Sector Equality Duty (PSED).
• Fluency in relevant models, techniques or methods and ability to contribute to developing new ones including: Mouse models of cancer (essential) Mammalian cell culture, including the experience of culturing challenging cell lines (e.g.
• Ewing sarcoma cells) Single molecule DNA fiber analysis Microscopy-based laboratory techniques (including immunofluorescence, DNA repair foci analysis, immunohistochemistry) Western blotting and immunoprecipitation Drug response assay, determination of IC50 etc.
• Analysis of big datasets (e.g.
• RNA-sequencing) Working with animals (not essential, but preferential).
• Mouse models of cancer (essential)
• Mammalian cell culture, including the experience of culturing challenging cell lines (e.g. Ewing sarcoma cells)
• Single molecule DNA fiber analysis
• Microscopy-based laboratory techniques (including immunofluorescence, DNA repair foci analysis, immunohistochemistry)
• Western blotting and immunoprecipitation
• Drug response assay, determination of IC50 etc.
• Analysis of big datasets (e.g. RNA-sequencing)
• Working with animals (not essential, but preferential).