Cryogenic Electron Microscopist support for the Dubochet Center for Imaging

This role is for a Cryogenic Electron Microscopist at EPFL's Dubochet Center for Imaging. Responsibilities include operating and maintaining cryo-EM instruments, preparing samples, acquiring and processing data for single-particle analysis and cryo-electron tomography, and supporting researchers with structural biology projects. A Ph.D. in structural biology or a related field with at least one year of hands-on cryo-EM experience, including data processing and instrument operation, is required.

• Strong motivation to explore new research domains
• As part of the DCI team, your responsibilities will include:
• Cryo-EM sample preparation
• Data acquisition for single-particle analysis (SPA) and cryo-electron tomography (cryo-ET)
• for single-particle analysis (SPA) and cryo-electron tomography (cryo-ET)
• On-the-fly and offline data processing, advanced image processing
• Structure determination and interpretation
• As a cryo-EM support, you will provide technical and scientific support to researchers from EPFL, UNIL as well as external customers, advising users throughout the different stages of their projects, from experimental planning and data acquisition to image processing and structure determination.
• You will also contribute to the continuous development and improvement of the DCI cryo-EM platform, helping to ensure a high level of service, reliability and performance for its users.
• Ph.D. in tructural biology or related field with experience in Cryo-EM
• At least one year of hands-on experience in cryo-EM, including instrument operation, facility support, training, data acquisition, data processing and/or cryo-ET
• Experience with cryo-EM image-processing software such as cryoSPARC, IMOD/eTomo, and Scipion
• Experience with SPA and/or cryo-ET workflows is desirable
• Good understanding of cryo-EM data acquisition and processing workflows
• Excellent communication skills in an English-speaking environment

• Service-oriented, proactive, and enthusiastic
• Practical and hands-on, with the flexibility to thrive in a dynamic, service-oriented platform
• Comfortable with change and able to adapt quickly to evolving priorities and workflows
• Reliable and committed to delivering high-quality results for all types of users and customers
• Collaborative, with clear communication skills and a constructive team spirit
• Able to work independently while contributing effectively to a team environment
• The position is based in the campus of EPFL and UNIL in Lausanne, Switzerland, and is available from 01 January 2027.
• It will initially be offered as a one-year contract, with the possibility of renewal.
• The position offers a competitive salary, and EPFL as well as UNIL are committed to being an equal opportunity employer.
• The Dubochet Center is currently equipped with three 300 kV Titan Krios with Cold-FEG and Falcon 4i direct electron detectors, and a Glacios 200 kV microscope.
• You will join a collaborative, international, and diverse research team from UNIL and EPLF with interdisciplinary expertise in biology, physics, computer science, and engineering.
• For more information about the Dubochet Center please visit our website: https://dci-lausanne.ch/ .
• Only applications submitted through the online platform are considered. You are asked to supply:
• A brief cover letter (pdf, up to 2 pages)