Bioinformatician – Single-Cell Omics in Vascular & Skeletal Muscle Biology 100%, Zurich, fixed-term 16.09.2026 | Department of Health Sciences and Technology (D-HEST) - Laboratory of Exercise and Health

This postdoctoral bioinformatician position focuses on leading single-cell and spatial transcriptomics analyses in vascular and skeletal muscle biology. Key responsibilities include designing and executing scRNAseq analyses, integrating diverse omics data, and developing computational tools for cell-cell communication. A PhD in bioinformatics or a related field with strong R/Python scripting skills and hands-on scRNAseq experience are required.

• Katrien De Bock at the Department of Health Sciences and Technology (D-HEST), ETH Zurich, is offering a fixed-term position for a bioinformatician (postdoctoral level) to lead the single-cell and spatial transcriptomics analyses within the laboratory of Exercise and Health.
• You will lead all single-cell and spatial transcriptomics work, working closely with an international team of PhD students and postdocs and in direct collaboration with Prof. De Bock. Specific responsibilities include:
• Apply and further develop computational tools for cell-cell communication analysis (ligand-receptor interactions and signaling pathways) and constraint based metabolic modeling tools (e.g. COMPASS, scFEA) to link transcriptional states to cell metabolism.
• Contribute to manuscript preparation, data visualization, and project reporting, and stay current with emerging single-cell and spatial genomics methods.
• Strong experience with collaborative development environments (e.g. GitHub/GitLab), version control, and maintaining well-documented, reusable repositories.
• A unique opportunity to lead the single-cell genomics workflow in a dynamic, collaborative, and internationally oriented lab.

• PhD degree in bioinformatics, computational biology, computational genomics, or a related quantitative field.
• prior research exposure to these fields is a plus but not required.
• You will have access to state-of-the-art infrastructure at ETH Zurich, dedicated computational resources, and close interactions with other bio-informaticians within the institute as well as the Functional Genomics Center Zurich ( www.fgcz.ch ).

• We offer a competitive salary in line with ETH Zurich regulations.